4 edition of Acquired Long QT Syndrome found in the catalog.
August 1, 2004
by Blackwell Publishing Limited
Written in English
|The Physical Object|
|Number of Pages||199|
Long-QT syndrome is a clinically and genetically heterogenous disorder of cardiac repolarization characterized electrocardiographically by heart-rate-corrected QT interval (QTc) prolongation and. Long QT syndrome is characterized by prolongation of the corrected QT (QTc) interval on the surface electrocardiogram and is associated with precipitation of torsade de pointes (TdP), a polymorphic ventricular tachycardia that may cause sudden death. Acquired long QT syndrome describes pathologic excessive prolongation of the QT interval, upon exposure to an environmental stressor, with.
Acquired long QT syndrome (aLQTS) is the most common form of LQTS, with drug-induced LQTS particularly common. Drugs implicated in aLQTS include antiarrhythmic agents such as quinidine or sotalol, tricyclic antidepressants, antibiotics (especially macrolide antibiotics such as erythromycin), antihistamines such as terfenidate, and inhalational. Long QT syndrome is a condition that can cause unusual heart rhythms. Learn what causes it and why it’s sometimes hard to diagnose. We’ll also go over risk factors and life expectancy.
the acquired long QT syndrome (aLQTS). All of them are thought to act at the level of KCNH2, a subunit of the potassium channel. Although the QT-prolonging drugs are proscribed in the subjects with aLQTS, the individual response to diverse QT-prolonging drugs may vary substantially. Congenital long QT syndrome (LQTS) has been the most investigated cardiac ion channelopathy. Although congenital LQTS remains the domain of cardiologists, cardiac electrophysiologists and specialised centres, the much more frequently acquired LQTS is the domain of physicians and other members of healthcare teams required to make therapeutic : Nabil El-Sherif, Gioia Turitto, Mohamed Boutjdir, Mohamed Boutjdir, Mohamed Boutjdir.
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Acquired Long QT Syndrome Secondary to Noncardiac Conditions (Pages: ). Acquired Long QT Syndrome has been added to your Cart Add to Cart.
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John Camm,available at Book Depository with free delivery worldwide. In recent years there has been considerable interest in the diagnosis and understanding of ventricular repolarisation, particularly the QT interval prolongation and abnormal T and T/U wave morphology associated with torsades de pointes.
Advances in ion channel cloning have greatly improved our understanding of the role of ionic channels in mediating cardiac repolarisation. The long QT syndrome (LQTS) is a disorder of myocardial repolarization characterized by a prolonged QT interval on the electrocardiogram (ECG).
This syndrome is associated with an increased risk of polymorphic ventricular tachycardia, a characteristic life-threatening cardiac arrhythmia also known as torsades de pointes (waveform 2A-B). Long QT syndrome (LQTS) is a condition in which repolarization of the heart after a heartbeat is affected.
It results in an increased risk of an irregular heartbeat which can result in fainting, drowning, seizures, or sudden death. These episodes can be triggered by exercise or stress.
Some rare forms of LQTS are associated with other symptoms and signs including deafness and periods of muscle. Acquired long QT syndrome is a disorder of cardiac repolarization most often due to specific drugs, hypokalemia, or hypomagnesemia that may precipitate torsade de pointes and cause sudden cardiac death.
Selzer and Wray first reported QT prolongation and ventricular fibrillation as a response to quinidine in Acquired LQTS Acquired long QT syndrome is the result of conditions, medications or events that prolong the QT interval. It is more common in women than men.
Stopping the medication and/or correcting the condition causing LQTS often resolves the issue. ISBN: OCLC Number: Description: vi, pages: illustrations ; 24 cm: Contents: Mechanisms of acquired QT prolongation and torsades de pointes --Measurement of the QT interval and repolarization assessment --Introduction to drug-induced long QT syndrome --Risk of QT prolongation and torsades de pointes with antiarrhythmic drugs --Risk of QT prolongation and.
The application of root mean square electrocardiography (RMS ECG) for the detection of acquired and congenital long QT syndrome. PLoS One, Jan 15; 9(1): e 5. Long QT syndrome (LQTS) is a cardiac electrophysiologic disorder, characterized by QT prolongation and T-wave abnormalities on the ECG that are associated with tachyarrhythmias, typically the ventricular tachycardia torsade de pointes (TdP).
TdP is usually self-terminating, thus causing a syncopal event, the most common symptom in individuals with LQTS. Long QT syndrome be inherited or acquired.
In other words, it can have root causes in your genes and start at birth, or come later in life due to some other cause. Continued. Acquired Long QT Syndrome 1st Edition, Kindle Edition by A. John Camm (Author) › Visit Amazon's A. John Camm Page.
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A Manufacturer: Wiley-Blackwell. Long QT syndrome (LQTS) is a congenital or acquired heart condition in which the QT interval (i.e., ventricular depolarization and repolarization) is prolonged.
Most patients with LQTS are asymptomatic, but some present with seizures, syncope, or. The vast majority of torsades results from acquired long-QT syndrome, which is the focus of this chapter. how to measure QT & QTc interval. The EKG computer will generally get this right, but it cannot be relied upon entirely.
QT may vary between leads. The lead with the longest easily measurable QT interval should be used. Long QT syndrome (LQTS) can be inherited or acquired. "Inherited" means you're born with the condition and have it your whole life.
Inherited conditions are passed from parents to children through genes. "Acquired" means you aren't born with the condition, but you develop it during your lifetime.
Inherited Long QT Syndrome. Mechanisms of acquired QT prolongation and torsades de pointes --Measurement of the QT interval and repolarization assessment --Introduction to drug-induced long QT syndrome --Risk of QT prolongation and torsades de pointes with antiarrhythmic drugs --Risk of QT prolongation and torsades de pointes with antihistamines --Risk of QT prolongation.
Acquired Long QT Syndrome In recent years there has been considerable interest in the diagnosis and understanding of ventricular repolarisation, particularly the QT interval prolongation and abnormal T and T/U wave morphology associated with torsades de pointes. Medical books Acquired Long QT Syndrome.
Acquired long QT syndrome is usually due to certain medications. Symptoms. Typically, the first signs of long QT may appear in early teens but there have been instances of symptoms showing in new-born babies and those of middle-age. Symptoms include: Unexplained seizures with no warning.
A sudden loss of consciousness may be mistaken or. Acquired Long QT Syndrome | Wiley In recent years there has been considerable interest in the diagnosis and understanding of ventricular repolarisation, particularly the QT interval prolongation and abnormal T and T/U wave morphology associated with torsades de pointes.
8 Risk of QT prolongation and torsades de pointes with antimicrobial and antimalarial drugs 9 Risk of QT prolongation and torsades de pointes with prokinetics and miscellaneous other drugs 10 Acquired long QT syndrome secondary to cardiac conditions 11 Acquired long QT syndrome secondary to noncardiac conditions The acquired Long QT Syndrome (aLQTS) is attributed to subtle defects in genes encoding potassium currents (Ik) that may become clinically significant when associated with other factors that impair ventricular repolarization, such as female gender, bradycardia, hypokalemia or the administration of ion channel blocking drugs.Kramer DB, Zimetbaum PJ.
Long-QT syndrome. Cardiol Rev. Sep-Oct;19(5); Kallergis EM, Goudis CA, Simantirakis EN, Kochiadakis GE, Vardas PE. Mechanisms, risk factors, and management of acquired long QT syndrome: a comprehensive review. ScientificWorldJournal. ; full-text; Roden DM. Drug-induced prolongation of the QT.